Journal article
A genome-wide linkage study of mammographic density, a risk factor for breast cancer
CMT Greenwood, AD Paterson, L Linton, IL Andrulis, C Apicella, A Dimitromanolakis, V Kriukov, LJ Martin, A Salleh, E Samiltchuk, RV Parekh, MC Southey, EM John, JL Hopper, NF Boyd, JM Rommens
Breast Cancer Research | BIOMED CENTRAL LTD | Published : 2011
DOI: 10.1186/bcr3078
Abstract
Introduction: Mammographic breast density is a highly heritable (h2 > 0.6) and strong risk factor for breast cancer. We conducted a genome-wide linkage study to identify loci influencing mammographic breast density (MD).Methods: Epidemiological data were assembled on 1,415 families from the Australia, Northern California and Ontario sites of the Breast Cancer Family Registry, and additional families recruited in Australia and Ontario. Families consisted of sister pairs with age-matched mammograms and data on factors known to influence MD. Single nucleotide polymorphism (SNP) genotyping was performed on 3,952 individuals using the Illumina Infinium 6K linkage panel.Results: Using a variance c..
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Awarded by National Institutes of Health
Funding Acknowledgements
This work was supported by the National Cancer Institute, National Institutes of Health under RFA-CA-06-503 and through cooperative agreements with members of the Breast Cancer Family Registry (BCFR) and Principal Investigators from Cancer Care Ontario (U01 CA69467), Cancer Prevention Institute of California (U01 CA69417), University of Melbourne (U01 CA69638), and the Research Triangle Institute (RTI) Informatics Support Center (RFP No. N02PC45022-46). The content of this manuscript does not necessarily reflect the views or policies of the National Cancer Institute or any of the collaborating centers in the BCFR, nor does mention of trade names, commercial products, or organizations imply endorsement by the US Government or the BCFR. The work was also supported by the National Institutes of Health (CA102659), Canadian Breast Cancer Research Alliance (016442) and the National Health and Medical Research Council of Australia.For the initial family analyses, genotyping services were provided by the Center for Inherited Disease Research (CIDR). CIDR is funded through a federal contract from the National Institutes of Health to The Johns Hopkins University, contract number HHSN268200782096C.